Mitochondrial malic enzyme polymorphism in Japanese population
نویسندگان
چکیده
منابع مشابه
Genetic control of mitochondrial malic enzyme in mouse brain.
A mitochondrial malic enzyme (EC 1.1.1.40; L-malate: NADP+ oxidoreductase (oxalacetate-decarboxylating) has been extensively purified from mouse heart and brain. The molecular weight of the enzyme was determined in the analytical ultracentrifuge to be 250,000 to 253,000. Sodium dodecyl sulfate-polyacrylamide gels showed one major polypeptide band of molecular weight 62,000. Thus, the native pro...
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Normal levels of mitochondrial malic enzyme were found in fibroblasts from three patients with Friedreich's ataxia.
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In a previous study [Bernstine, E.G. (1979) J. Biol. Chem. 254, 83-87] it was shown that inbred strains of mice fall into two classes based on the specific activity of mitochondrial malic enzyme [L-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating), EC 1.1.1.40] in brain. In this report we demonstrate differences between high- and low-activity strains in the development of enzyme activi...
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In islet beta-cells and INS-1 cells both the high activity of malic enzyme and the correlation of insulin secretion rates with pyruvate carboxylase (PC) flux suggest that a pyruvate-malate cycle is functionally relevant to insulin secretion. Expression of the malic enzyme isoforms in INS-1 cells and rat islets was measured, and small interfering RNA was used to selectively reduce isoform mRNA e...
متن کاملBovine heart malic enzyme. I. Isolation and partial purification of a cytoplasmic and a mitochondrial enzyme.
Homogenates prepared from bovine heart muscle contain two distinct forms of malic enzyme (malate:NADP+ oxidoreductase (decarboxylating), EC 1.1.1.40), which can be easily separated by chromatography on DEAE-cellulose. A partial purflcation of the two enzymes has been accomplished by means of DEAE-cellulose chromatography, ammonium sulfate fractionation, and chromatography on CMSephadex. The iso...
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ژورنال
عنوان ژورنال: Japanese journal of human genetics
سال: 1983
ISSN: 0021-5074
DOI: 10.1007/bf01897043